Referensi Katrangan
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Jeneng Produk: |
Diethyl malonate |
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Sinonim: |
ESTER DIETHYL ACID MALONIK; ESTER MALONIK; ETHYL MALONATE; Etil propanedioate; FEMA 2375; DEM; DICARBETHOXYMETHANE; DIETHYL MALONATE |
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CAS: |
105-53-3 |
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MF: |
C7H12O4 |
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MW: |
160.17 |
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EINECS: |
203-305-9 |
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Kategori Produk: |
Blok Bangunan; C6 nganti C7; Senyawa Carbonyl; Sintesis Kimia; Ester; Organik; Blok Bangunan Organik |
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File Mol: |
105-53-3.mol |
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Titik lebur |
-50 ° C |
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Titik didih |
199 ° C (surem) |
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kapadhetan |
1,055 g / mL ing suhu 25 ° C (lit.) |
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kerapatan uap |
5.52 (vs hawa) |
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tekanan uap |
1 mm Hg (40 ° C) |
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FEMA |
2375 | DIETHYL MALONATE |
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indeks bias |
n20 / D 1.413 (surem) |
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Fp |
212 ° F |
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temp panyimpenan |
Simpen ing ngisor + 30 ° C. |
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kelarutan |
20.8g / l (MSDS Eksternal) |
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pka |
13.5 (jam 25â „ƒ) |
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wujud |
Cairan |
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watesan bledosan |
0,8-12,8% (V) |
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Kelarutan Banyu |
Miscible karo etil alkohol, eter, kloroform lan benzena. Rada miscible karo banyu. |
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Nomer JECFA |
614 |
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Merck |
14.3233 |
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BRN |
774687 |
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Stabilitas: |
Mantep Bisa dibakar Kompatibel karo agen oksidasi sing kuat, |
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InChIKey |
IYXGSMUGOJNHAZ-UHFFFAOYSA-N |
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Referensi CAS DataBase |
105-53-3 (Referensi CAS DataBase) |
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Referensi Kimia NIST |
Asam propanedioat, eset diethil (105-53-3) |
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Sistem Registrasi Bahan EPA |
Diethyl malonate (105-53-3) |
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Kode Bahaya |
Xi |
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Pernyataan Risiko |
36/37 / 38-36 |
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Pernyataan Keamanan |
24 / 25-26 |
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WGK Jerman |
1 |
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RTECS |
OO0700000 |
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Suhu Otomatis |
435 ° C DIN 51794 |
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Cathetan Bahaya |
Ngirit |
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TSCA |
Nggih |
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Kode HS |
29171910 |
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Keracunan |
LD50 kanthi lisan ing Kelinci: 15720 mg / kg Kelinci dermal LD50> 16000 mg / kg |
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Properti Kimia |
cairan tanpa warna |
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Properti Kimia |
Diethyl malonate duwe ambu ora enak, nyenengake, lan wangi. |
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Migunakake |
Pabrik barbiturat. |
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Preparasi |
Reaksi asam kloroaketik dadi asam sianatetik nggunakake sodium sianida lan saponifikasi sabanjure; asam malonic pungkasane diukur kanthi distilasi azeotropic karo etanol ing benzena |
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Nilai ambang rasa |
Karakteristik rasa ing 50 ppm: manis lan woh kanthi nuansa apel lan nanas. |
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Profil Keamanan |
Ringan kanthi beracun amarga asupan. Iritasi kulit. Cairan sing bisa dibakar nalika kena panas utawa geni; bisa reaksi karo bahan oksidasi. Kanggo nglawan geni, gunakake banyu kanggo geni kemul, busa, CO2, bahan kimia garing. Yen digawe panas dadi dekomposisi, dheweke bakal ngetokake asap akut lan asap asap. Deleng uga ESTERS. |
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Metode Pemurnian |
Yen banget ora murni (IR, NMR) ester (250g) digawe panas ing adus uap sajrone 36 jam kanthi EtOH absolut (125mL) lan conc H2SO4 (75mL), mula banjur distilasi kanthi tekanan suda. Yen ora, pecah sacara fraksi kanthi tekanan suda lan kumpulake fraksi tengah sing wis umob. [Beilstein 2 IV 1881.] |
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Produk Preparasi |
2-HEXYLDECANOIC ACID -> CYCLOPENTYLACETIC ACID -> 5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER -> Enoxacin -> Phenylbutazone -> 4,6-Dichloro-2- (methylsulfonyl)> 2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER -> 5-NITROBENZOFURAN-2-CARBOXYLIC ACID -> 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE -> Diethyl chloromLATE-2ZL-CART-2 -> 5,7-BIS (TRIFLUOROMETHYL) -4-CHLOROQUINOLINE -> 2-Mercapto-4,6-dimethoxypyrimidine -> 4-Chloro-6-methoxy-2- (methylthio) pyrimidine, 98% -> 5,7-BIS (TRIFLUOROMETHYL) -4-HYDROXYQUINOLINE -> 2- (TRIFLUOROMETHYL) -4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID -> Asam 5-Nitropyridine-2-karboksilat asam -> asam 2-ETHOXY ESTER -> 2,4-Dihydroxypyrimidine-5-carboxylic acid -> 4,6-Dihydroxy-2-methylpyrimidine -> 5,7-BIS (TRIFLUOROMETHYL) -4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID -> 4 -Chloro-7- (trifluoromethyl) quinolin -> ETHYL 4-CHLORO-6- (TRIFLUOROMETHYL) -3-QUINOLINECARBOXYLATE -> 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINL-E-ACBOX -> TRIETHYL 1,1,2-ETHANETRICARBOXYLATE -> ETHYL 2- (ETHYLTHIO) -4-HYDROXYPYRIMIDINE-5-CARBOXYLATE -> 2,4,5-Trifluorophenylacetic acid -> Gliclazide -> 2-MERCAPTOP 4 , 6-DIOL -> ETHYL 4-HYDROXY-6- (TRIFLUOROMETHYL) QUINOLINE-3-CARBOXYLATE -> Diethyl butylmalonate -> 2-AMINODIETHYLMALONATE -> 2-amino-6-chloropyrimidin-4 (3H) -one -> 3-CARBETHOXYUMBELIFERONE -> DIETHYL 2- (2-CYANOETHYL) MALONATE -> 5-CARBETHOXYURACIL -> 3-CARBETHOXY-2-PIPERIDONE -> 2-Amino-6-hydroxypyrimidin-4 (3H) - siji, 97% -> Sulfamonomethoxine |
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Bahan baku |
Etanol -> Asam hidroklorat -> Asam sulfat -> Natrium karbonat -> Natrium sianida -> Asam malonat -> Asam klorasat -> Asam natrium asam kloraketat -> Asam sianatetik -> Disodium hidrogenorthofosfat-- > Garam DISODIUM asam asam malonis |
